Summary
The study, “A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder,” explores hyperbaric oxygen therapy (HBOT) as a novel treatment for veterans suffering from traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) following blast exposure. Given the high incidence of these conditions among military personnel, traditional treatments for PTSD and TBI symptoms have limited efficacy, particularly for cases with combined diagnoses. This study seeks to assess the safety and effectiveness of low-pressure HBOT at 1.5 atmospheres absolute (ATA) in improving symptoms and brain function in affected veterans.
Methodology
Sixteen military subjects with chronic mild-to-moderate TBI and PTSD were selected for this study. Each participant underwent a comprehensive baseline assessment, including symptom review, physical and neurological exams, psychological testing, and single photon emission computed tomography (SPECT) brain imaging. Participants received 40 HBOT sessions over 30 days, with each session conducted at 1.5 ATA for 60 minutes. Post-treatment evaluations, including symptom checks, exams, cognitive tests, and brain imaging, were conducted within a week of completing the treatment course to assess improvements.
Results
The results indicated substantial improvement in cognitive function, mood, and overall quality of life. Subjects demonstrated increased IQ scores, enhanced memory functions, and reduced symptoms of PTSD and depression. SPECT imaging showed better brain blood flow, with noted improvements in both white and gray matter after one and forty HBOT sessions. Transient side effects included mild ear barotrauma, temporary symptom exacerbation in four participants, and a single case of reversible bronchospasm.
Conclusion
This study suggests that low-pressure HBOT may be a promising treatment option for veterans with blast-induced TBI and PTSD, particularly in enhancing cognitive functions and alleviating symptoms. The marked improvements in brain blood flow observed in SPECT imaging further reinforce the potential of HBOT as a safe and effective intervention for these conditions. The findings support the need for further research on hyperbaric therapy as a treatment pathway for chronic TBI and PTSD, focusing on its safety and long-term benefits.
Source
Paul G Harch, Susan R Andrews, Edward F Fogarty, Daniel Amen, John C Pezzullo, Juliette Lucarini, Claire Aubrey, Derek V Taylor, Paul K Staab, Keith W Van Meter | PMID: 22026588 | DOI: 10.1089/neu.2011.1895