Summary of Study
The study, “Hyperbaric Oxygen Therapy for the Treatment of Radiation-Induced Sequelae in Children: The University of Pennsylvania Experience”, aimed to assess the effectiveness of hyperbaric oxygen therapy (HBOT) in children with radiation-induced complications. The goal was to determine if hyperbaric therapy could support recovery and prevent long-term issues following radiation treatment.
Methodology
Researchers observed 10 children treated with radiation who then received hyperbaric oxygen therapy between 1989 and 1994. Six patients received hyperbaric treatment prophylactically before dental or surgical procedures, while four patients underwent hyperbaric therapy to treat radiation-induced conditions like osteoradionecrosis and vasculitis. Treatments involved 9-40 sessions at 2 atmospheres absolute for 2 hours each.
Results
Most children tolerated the hyperbaric therapy well, with only mild side effects like initial nausea in two patients. All six patients in the prophylactic group showed complete healing in the affected areas. In the therapeutic group, three patients exhibited bone regrowth, and one showed initial improvement in hearing that later returned to baseline.
Conclusion
Hyperbaric oxygen therapy proved to be a safe and effective treatment for children with radiation-related complications, enhancing healing and reducing long-term damage. This study suggests that hyperbaric therapy can be a valuable tool in managing radiation-induced injuries in pediatric patients.
Source: Hyperbaric oxygen therapy for the treatment of radiation-induced sequelae in children: The University of Pennsylvania experience | Hani L. Asharnalla, M.D. | Joel W. Goldwein, M.D | Stephen R. Thorn, M.D., Ph.D