Effects of Pressurized Oxygen in Acute Brain Insult

From the 3rd International Symposium for Cerebral Palsy and Brain-Injured Child

Effects of Pressurized Oxygen in Acute Brain Insult

  • Reduces cerebral edema & ICP
  • Limits the ischemic cascade
  • Reduces CNS lactate peak in hypoxia
  • Neutralizes toxic amines
  • Deaggragation of platelets
  • Increases Phagocytic activity of PMN cells (white blood cells)
  • Reduces Adhesiveness of WBCs to endothelium
  • Perfuses all tissues spaces
  • Life sustaining O2 available via retrograde perfusion in absence of a trickle phenomena
  • Delivers metabolically available O2 without chemical energy transfer – Enough to sustain life without blood
  • Under pressure O2 adheres to all the gas laws of physics
  • Displaces all other gases in the body: N2, CO
  • Follows the Law of Mass Action
  • Completely saturates hemoglobin
  • Increases plasma O2 by 2000%
  • Dissolves in cerebrospinal fluid, lymph, bone, and urine

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Effects of Pressurized Oxygen in Chronic Brain Insult

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  • Reactivates idling neurons
  • Enhances plasticity
  • Efficiently elevates diffusional driving force for O2 thereby increasing tissue oxygen availability
  • Promotes phagocytosis (internal debridement)
  • Ameliorates multiple biochemical changes
  • Restores the integrity of the blood brain barrier and cell membranes
  • Improves cell respiration, Reduces cell byproducts – cytokines
  • Promotes Neovascularization
  • Promotes Epithelization
  • Acts as scavenger of free radicals
  • Bacteriostatic effects, synergizes with certain antibiotics
  • Neutralizes certain Toxins: Clostridium, anaerobes
  • Stimulates the adaptive immune system, especially in elderly (mice)